Background and objective: Code status discussions may fail to address patients’ treatment-related goals and their knowledge of cardiopulmonary resuscitation (CPR). This study aimed to investigate patients’ resuscitation preferences, knowledge of CPR and goals of care. Design, setting, patients and measurements: 135 adults were interviewed within 48 h of admission to a general medical service in an academic medical centre, querying code status preferences, knowledge about CPR and its outcome probabilities and goals of care. Medical records were reviewed for clinical information (...) and code status documentation. Results: 41 (30.4%) patients had discussed CPR with their doctor, 116 (85.9%) patients preferred full code status and 11 (8.1%) patients expressed code status preferences different from the code status documented in their medical record. When queried about seven possible goals of care, patients affirmed an average of 4.9 goals; their single most important goals were broadly distributed, ranging from being cured (n = 36; 26.7%) to being comfortable (n = 8; 5.9%). Patients’ mean estimate of survival to discharge after CPR was 60.4%. Most patients believed it was helpful to discuss goals of care (n = 95; 70.4%) and the chances of surviving inhospital CPR (n = 112; 83.0%). Some patients expressed a desire to change their code status after receiving information about survival following inhospital CPR (n = 11; 8.1%) or after discussing goals of care (n = 2; 1.5%). Conclusions: Doctors need to address patients’ knowledge about CPR and take steps to avoid discrepancies between treatment orders and patients’ preferences. Addressing CPR outcome probabilities and goals of care during code status discussions may improve patients’ knowledge and influence their preferences. (shrink)

ObjectiveTo further delineate risk and resilience factors contributing to trajectories of mental health symptoms experienced by college students through the pandemic.Participantsn = 183 college students.MethodsLinear mixed models examined time effects on depression and anxiety. Propensity-matched subgroups exhibiting “increased” versus “low and stable” depression symptoms from before to after the pandemic-onset were compared on pre-pandemic demographic and psychological factors and COVID-related experiences and coping strategies.ResultsStudents experienced worsening of mental health symptoms throughout the pandemic, particularly during Fall 2020 compared with Fall 2019. (...) The propensity-matched subgroup exhibiting relative resilience reported less alcohol use prior to the pandemic, greater use of active coping strategies, and less of an impact on their college progress.ConclusionsResults point to several potential targets of screening and intervention to decrease residual impacts of the pandemic. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

This monograph attempts to clarify one significant but much neglected aspect of Peirce's contribution to the philosophy of science. It was written in 1963 as my M. A. thesis at the Uni versity of Illinois. Since the topic is still neglected it is hoped that its pUblication will be of use to Peirce scholars. I should like to acknowledge my indebtedness to Dr. Max Fisch who broached this topic to me and who advised me con tinuously through its development, assisting (...) generously with his own insights and unpublished Peirce manuscripts. TABLE OF CONTENTS INTRODUCTION 1. A Current Issue in the Philosophy of Science 1 2. Peirce and His Theory of Abduction 5 3. The General Character of Abduction 7 PART I: THE EARLY THEORY 1. Peirce's Earliest Conception of Inference 11 2. Three Kinds of Inference and Three Figures of Syllogism 13 3. Ampliative Inference and Cognition 17 4. Induction and Hypothesis 20 5. The Method of Methods 23 PART II: THE LATER THEORY 1. The Transitional Period 28 2. Three Stages of Inquiry 31 3. Abduction and Guessing Instinct 35 4. Logic as a Normative Science 38 5. Hypothesis Construction and Selection 41 6. Abduction and Pragmatism 44 7. Economy of Research 47 8. Justification of Abduction 51 CONCLUSION 55 61 BIBLIOGRAPHY INTRODUCTION 1. (shrink)

There is a unique relationship between Maoist policies and philosophy. This uniqueness is idue, on the one hand, to the pedagogical orientation of the CPC, and to the essential role of the cultural revolution, on the other.

Meiotic recombination occurs preferentially at certain regions called hot spots and is important for generating genetic diversity and proper segregation of chromosomes during meiosis. Hot spots have been characterized most extensively in yeast, mice and humans. The development of methods based on sperm typing and population genetics has facilitated rapid and high‐resolution mapping of hot spots in mice and humans in recent years. With increasing information becoming available on meiotic recombination in different species, it is now possible to compare several (...) molecular features associated with hot‐spot loci. Further, there have been advances in our knowledge of the factors influencing hot‐spot activity and the role that they play in structuring the genome into haplotype blocks. We review the molecular features associated with hot spots in terms of their properties and mechanisms underlying their function and distribution. A large number of these features seem to be shared among hot spots from different species suggesting common mechanisms for their formation and function. BioEssays 28:45–56, 2006. © 2005 Wiley Periodicals, Inc. (shrink)

On April 3, 1995, the Fourth Circuit upheld the right of a Maryland hospital to terminate a surgeon who was HIV-positive ). A resident in the University of Maryland Neurosurgical Training Program was dismissed when hospital administrators learned of his infection with HIV. The resident, known as Dr. Doe, claimed that his termination violated federal laws protecting persons with disabilities. The court upheld the hospital's actions as lawful and affirmed the trial court's grant of summary judgment for the hospital.Dr. Doe (...) charged that his dismissal from the training program violated the Rehabilitation Act and the Americans with Disabilities Act. (shrink)

Graphical AbstractGroup photo of the participants at the chromosome stability meeting in Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India. The meeting brought together the Indian scientific community and investigators from other countries working on various aspects of chromosome stability.

The editor has arranged forty-nine essays on and by Santayana into eight chapters representing major areas of Santayana's thought such as "Materialism and Idealism," "Essence, Substance, and Existence," "Art and Beauty." The essays supposedly speak to their chapter titles and to each other to create "the sense of dialogue"; with a few exceptions they were not written as deliberate conversation. This "dialogue" treats the reader to a fine display of the variety of minds and interests at work in philosophy and (...) illustrates the fact that one man's philosophical arena is rarely another man's. From J. H. Randall, Jr. to John Crowe Ransom, a recurring point of contention is Santayana's conception of Essences and their relationship to Matter. The range of interpretation on this issue goes from plaintive objections that "Essences don't do anything!" to appreciative acknowledgment that "Essences don't do anything!". Arguments over "isms" abound; realism, idealism, epiphenominalism are examined from many angles besides Santayana's. Santayana is highlighted nicely, arranged in this way beside his critics. His ability to locate the vital force behind an idea and to indicate where specific thrusts of thought will lead evinces his title of philosopher and master critic. This collection is not limited in appeal to Santayana aficionados.--A. K. T. (shrink)

The twenty-two essays collected for this book range widely in theme, style, and quality. The essays, a majority of which were previously unpublished, are arranged in three sections: 1) Early Essays, containing one particularly fine essay, "The Soul at Play," originally intended as part of Santayana's Soliloquies in England; 2) Later Essays, in which the title essay and "Friendship" are outstanding; and 3) Philosophical Essays, offering commentaries on Russell, Dewey, and James, on his own philosophy, and "On the False Steps (...) of Philosophy." The book's last article, "What is the Ego?", is an elaboration of his criticism of those "German Prophets" who return from self-contemplation "as greedy as children and as stubborn as Inquisitors." Santayana's manner of exposition often involves the elaboration of a single image or metaphor. When an image or metaphor is employed which can bear the weight of subtle distinctions, he is brilliant; but when the metaphor is too weak to encompass his thinking, then his writing becomes flowery and decadent. The essays, unfinished and fragmentary for the most part, are frequently little more than a single extended metaphor--sometimes over-extended. The fragmentary, possibly only experimental, ideas in these essays invite comparison with their use in his completed works. The book will be of special interest to someone already familiar with Santayana.--A. K. T. (shrink)

JL Austin exercised in Post-war Oxford an intellectual authority similar to that of Wittgenstein in Cambridge. Although he completed no books of his own and published only seven papers, Austin became through lectures and talks one of the acknowledged leaders in what is called ‘Oxford philosophy’ or ‘ordinary language philosophy’. Few would dispute that among analytic philosophers Austin stands out as a great and original philosophical genius. Three volumes of his writing, published after his death, have become classics in analytical (...) philosophy: _Philosophical Papers_; _Sense and Sensibilia_; and _How to Do Things with Words_. First published in 1979, this book is a collection of critical essays on Austin’s philosophy written by well-known philosophers, many of whom knew Austin personally. A number of essays included were especially written for this volume, but the majority have appeared previously in various journals or books, not all easy to obtain. (shrink)

The emerging field known as experimental philosophy has expanded into moral philosophy: by presenting experimental subjects with vignettes describing scenarios with moral implications, data about people's moral intuitions are gathered and analyzed. This paper examines the adequacy of applying the common methodology of experimental philosophy to the study of moral thought. By employing Raimond Gaita's notion of moral seriousness and his distinction between form and content, it argues that the kind of empirical research on moral intuitions conducted by experimental philosophers (...) fails to take into consideration some fundamental characteristics of moral thinking. (shrink)

The double issue of Synthese devoted to essays on the work of W. V. Quine has been re-issued under hard cover with an additional paper by Grice on "Vacuous Names" and a 13-page bibliography of Quine's writings. With the exception of Berry's "Logic with Platonism" and Jensen's "On The Consistency of a Slight. Modification of Quine's New Foundation," the papers are concerned with the key issues of Word and Object. Quine's responses to each of the contributors are not as helpful (...) as they might be, but are at times quite illuminating. He dispels Stenius's view in "Beginning with Ordinary Things" that Quine holds a Russellian epistemology, for example, and clarifies somewhat his account of ontic commitment in replying to Hintikka's "Behavioral Criteria of Radical Translation." Hintikka argues that "to be is to be a value of a bound variable" presupposes the principle, "to be is to be an object of search." Quine rejects this view, identifying his ontology with the range of the variables as opposed to the class of all things to which a theory is ontically committed. The introduction to chapter two of Word and Object by Harman is quite helpful, suggesting among other things that Quine's use of 'propositional attitude' is a misnomer to be better replaced by 'sentential attitude'. An interesting and provocative paper by Kaplan offers a Fregean alternative to Quine's general mode of handling referentially opaque contexts, allowing "Quantifying In" with the variable ranging over expressions. Interestingly enough, Quine's remarks are rather laudatory and sympathetic. Davidson's "On Saying That" suggests a roughly similar account of oratio obliqua discourse. Føllesdal and Sellars discuss "Quine on Modality" and "Some Problems about Belief." There is a discussion of "Quine's Philosophy of Science" by Smart, tracing a shift from instrumentalism to realism on the part of Quine. Also included are papers by Chomsky, Stroud, and Geach, as well as Strawson's familiar "Singular Terms and Predication." In spite of the imposing price and the uneven quality of the essays, the book is a desirable piece of Quineana.--K. T. (shrink)

In this work we analyze the case of resistive conductor plates carrying constant currents, utilizing surface charge distributions. We obtain the electric potential in the plates and in the space surrounding them. We obtain a non-vanishing electric field outside the conductors. We compare the theoretical results with experimental data present in the literature.